The association between internal polycyclic aromatic hydrocarbons exposure and risk of Obesity-A systematic review with meta-analysis

Chunyu Liu; Qisijing Liu; Shanjun Song; Weixia Li; Yuanyuan Feng; Xiangru Cong; Yaqin Ji; Penghui Li

doi:10.1016/j.chemosphere.2023.138669

The association between internal polycyclic aromatic hydrocarbons exposure and risk of Obesity-A systematic review with meta-analysis

Chemosphere. 2023 Jul:329:138669. doi: 10.1016/j.chemosphere.2023.138669. Epub 2023 Apr 12.

Authors

Chunyu Liu¹, Qisijing Liu², Shanjun Song³, Weixia Li¹, Yuanyuan Feng¹, Xiangru Cong¹, Yaqin Ji⁴, Penghui Li⁵

Affiliations

¹ School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China.
² Research Institute of Public Health, Nankai University, Tianjin, 300071, China.
³ School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China; Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, 300384, China; National Institute of Metrology, Beijing, 100029, China. Electronic address: songsj@nim.ac.cn.
⁴ College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, China.
⁵ School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China; Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, Tianjin, 300384, China. Electronic address: lipenghui406@163.com.

PMID: 37059208
DOI: 10.1016/j.chemosphere.2023.138669

Abstract

Exposure to polycyclic aromatic hydrocarbons (PAHs) is emerging as a risk factor for obesity, but with conflicting findings. The aim of this systematic review is to investigate and summarize the current evidence towards the associations between PAHs exposure and risk of obesity. We conducted a systematic search of online databases, including PubMed, Embase, Cochrane Library, and Web of Science up to April 28, 2022. Eight cross-sectional studies with data from 68,454 participants were included. The present study illustrated that there was a significant positive association between naphthalene (NAP), phenanthrene (PHEN), and total OH-PAH metabolites and risk of obesity, the pooled OR (95% CI) was estimated at 1.43 (1.07, 1.90), 1.54 (1.18, 2.02), and 2.29 (1.32, 3.99), respectively. However, there was no significant association between fluorene (FLUO) and1-hydroxypyrene (1-OHP) metabolite and risk of obesity. Subgroup analyses showed that associations between PAHs exposure and risk of obesity were more apparent in children, female, smokers and developing regions.

Keywords: Meta-analysis; Obesity; Polycyclic aromatic hydrocarbons; Systematic review.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Biomarkers
Child
Cross-Sectional Studies
Female
Humans
Obesity / chemically induced
Obesity / epidemiology
Polycyclic Aromatic Hydrocarbons*
Risk Factors

Substances

Polycyclic Aromatic Hydrocarbons
Biomarkers