The management of oligometastatic disease in colorectal cancer: Present strategies and future perspectives

Crit Rev Oncol Hematol. 2023 Jun:186:103990. doi: 10.1016/j.critrevonc.2023.103990. Epub 2023 Apr 13.


Oligometastatic disease has been described as an intermediate clinical state between localized cancer and systemically metastasized disease. Recent clinical studies have shown prolonged survival when aggressive locoregional approaches are added to systemic therapies in patients with oligometastases. The aim of this review is to outline the newest options to treat oligometastatic colorectal cancer (CRC), also considering its molecular patterns. We present an overview of the available local treatment strategies, including surgical procedures, stereotactic body radiation therapy (SBRT), thermal ablation, as well as trans-arterial chemoembolization (TACE) and selective internal radiotherapy (SIRT). Moreover, since imaging methods provide crucial information for the early diagnosis and management of oligometastatic CRC, we discuss the role of modern radiologic techniques in selecting patients that are amenable to potentially curative locoregional treatments.

Keywords: Colorectal cancer (CRC); Oligometastatic disease (OMD); Radiofrequency ablation (RFA); Selective internal radiotherapy (SIRT); Stereotactic body radiation therapy (SBRT); Trans-arterial chemoembolization (TACE).

Publication types

  • Review

MeSH terms

  • Brachytherapy*
  • Colorectal Neoplasms* / diagnosis
  • Colorectal Neoplasms* / pathology
  • Colorectal Neoplasms* / therapy
  • Humans
  • Radiosurgery* / methods