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. 2023 Jul;118(1):27-33.
doi: 10.1016/j.ajcnut.2023.04.013. Epub 2023 Apr 13.

Higher intake of dietary flavonols, specifically dietary quercetin, is associated with lower odds of frailty onset over 12 years of follow-up among adults in the Framingham Heart Study

Steven Oei  1 , Courtney L Millar  2 , Thuy Nga Nguyen Lily  3 , Kenneth J Mukamal  4 , Douglas P Kiel  2 , Lewis A Lipsitz  2 , Marian T Hannan  2 , Shivani Sahni  5
Affiliations

Higher intake of dietary flavonols, specifically dietary quercetin, is associated with lower odds of frailty onset over 12 years of follow-up among adults in the Framingham Heart Study

Steven Oei et al. Am J Clin Nutr. 2023 Jul.

Abstract

Background: Polyphenolic antioxidants derived from plant foods may reduce oxidative stress and frailty, but the effect of the polyphenol subclass of dietary flavonoids and their subclasses on frailty is uncertain.

Objectives: To determine the association between dietary flavonoids, their subclasses, quercetin (a specific flavonol), and frailty onset in adults.

Methods: This prospective cohort study included individuals from the Framingham Heart Study with no frailty at baseline. Intake of total flavonoids, subclasses of flavonoids (flavonols, flavan-3-ols, flavonones, flavones, anthocyanins, and polymeric flavonoids), and quercetin were estimated via semi-quantitative FFQ along with frailty (Fried phenotype), and covariates at baseline (1998-2001). Frailty was re-evaluated in 2011-2014. Logistic regression estimated OR and 95% CIs for each flavonoid variable and frailty onset.

Results: Mean age was 58.4 y (SD ± 8.3, n = 1701; 55.5% women). The mean total flavonoid intake was 309 mg/d (SD ± 266). After 12.4 (SD ± 0.8) y, 224 (13.2%) individuals developed frailty. Although total flavonoid intake was not statistically associated with frailty onset (adjusted OR: 1.00; 95% CI: 0.99-1.01), each 10 mg/d of higher flavonol intake was linked with 20% lower odds of frailty onset (OR: 0.80; 95% CI: 0.67-0.96). Other subclasses showed no association (P values range: 0.12-0.99), but every 10 mg/d of higher quercetin intake was associated with 35% lower odds of frailty onset (OR: 0.65; 95% CI: 0.48-0.88).

Conclusions: Although no association was observed between total flavonoid intake and frailty onset in adults, a higher intake of flavonols was associated with lower odds of frailty onset, with a particularly strong association for quercetin. This hypothesis-generating study highlights the importance of assessing specific subclasses of flavonoids and the potential of dietary flavonols and quercetin as a strategy to prevent the development of frailty.

Keywords: flavonoids; flavonols; frailty; older adults; quercetin.

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Figures

Figure 1
Figure 1
Inclusion and exclusion criteria for Framingham Heart Study - Offpsring Cohort participants included in this analysis. FFQ, Food Frequency Questionnaire; FHS, Framingham Heart Study.
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References

    1. Yannakoulia M., Ntanasi E., Anastasiou C.A., Scarmeas N. Frailty and nutrition: from epidemiological and clinical evidence to potential mechanisms. Metabolism. 2017;68:64–76. doi: 10.1016/j.metabol.2016.12.005. - DOI - PubMed
    1. Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., et al. Frailty in older adults: evidence for a phenotype. J. Gerontol. A. Biol. Sci. Med. Sci. 2001;56(3):M146–M156. doi: 10.1093/gerona/56.3.m146. - DOI - PubMed
    1. Kojima G., Liljas A.E.M., Iliffe S. Frailty syndrome: implications and challenges for health care policy. Risk Manag. Healthc. Policy. 2019;12:23–30. doi: 10.2147/RMHP.S168750. - DOI - PMC - PubMed
    1. Giné-Garriga M., Roqué-Fíguls M., Coll-Planas L., Sitjà-Rabert M., Salvà A. Physical exercise interventions for improving performance-based measures of physical function in community-dwelling, frail older adults: a systematic review and meta-analysis. Arch. Phys. Med. Rehabil. 2014;95(4):753–769.e3. doi: 10.1016/j.apmr.2013.11.007. - DOI - PubMed
    1. Tarazona-Santabalbina F.J., Gómez-Cabrera M.C., Pérez-Ros P., Martinez-Arnau F.M., Cabo H., Tsaparas K., et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J. Am. Med. Dir. Assoc. 2016;17(5):426–433. doi: 10.1016/j.jamda.2016.01.019. - DOI - PubMed

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