[New update to the guidelines on testing predictive biomarkers in non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology]

Rev Esp Patol. 2023 Apr-Jun;56(2):97-112. doi: 10.1016/j.patol.2023.02.002. Epub 2023 Mar 28.
[Article in Spanish]


Non-small cell lung cancer (NSCLC) presents the greatest number of identified therapeutic targets, some of which have therapeutic utility. Currently, detecting EGFR, BRAF, KRAS and MET mutations, ALK, ROS1, NTRK and RET translocations, and PD-L1 expression in these patients is considered essential. The use of next-generation sequencing (NGS) facilitates precise molecular diagnosis and allows the detection of other emerging mutations, such as the HER2 mutation and predictive biomarkers for immunotherapy responses. In this consensus, a group of experts in the diagnosis and treatment of NSCLC selected by the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM) have evaluated currently available information and propose a series of recommendations to optimize the detection and use of biomarkers in daily clinical practice.

Keywords: ALK; BRAF; Biomarcadores; Biomarkers; Carcinomas de pulmón no célula pequeña; EGFR; Non-small cell lung cancer; PD-L1; ROS1.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Carcinoma, Non-Small-Cell Lung* / genetics
  • Carcinoma, Non-Small-Cell Lung* / therapy
  • Consensus
  • Humans
  • Lung Neoplasms* / pathology
  • Medical Oncology
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins / genetics


  • Protein-Tyrosine Kinases
  • Biomarkers, Tumor
  • Proto-Oncogene Proteins