Non-coding RNAs: The recently accentuated molecules in the regulation of cell autophagy for ovarian cancer pathogenesis and therapeutic response

Bi Peng; Jing Li; Yuanliang Yan; Yuanhong Liu; Qiuju Liang; Wei Liu; Abhimanyu Thakur; Kui Zhang; Zhijie Xu; Jian Wang; Fan Zhang

doi:10.3389/fphar.2023.1162045

Non-coding RNAs: The recently accentuated molecules in the regulation of cell autophagy for ovarian cancer pathogenesis and therapeutic response

Front Pharmacol. 2023 Mar 31:14:1162045. doi: 10.3389/fphar.2023.1162045. eCollection 2023.

Authors

Bi Peng¹, Jing Li², Yuanliang Yan³, Yuanhong Liu³, Qiuju Liang^{3

4}, Wei Liu^{1

5}, Abhimanyu Thakur⁶, Kui Zhang⁷, Zhijie Xu¹, Jian Wang², Fan Zhang⁸

Affiliations

¹ Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Pharmacy, Shanghai Pudong New Area People's Hospital, Shanghai, China.
³ Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁵ Department of Orthopedic Surgery, The Second Hospital University of South China, Hengyang, Hunan, China.
⁶ Ben May Department for Cancer Research, Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States.
⁷ State Key Laboratory of Silkworm Genome Biology, Medical Research Institute, Southwest University, Chongqing, China.
⁸ Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Abstract

Autophagy is a self-recycling and conserved process, in which the senescent cytoplasmic components are degraded in cells and then recycled to maintain homeostatic balance. Emerging evidence has suggested the involvement of autophagy in oncogenesis and progression of various cancers, such as ovarian cancer (OC). Meanwhile, the non-coding RNAs (ncRNAs) frequently regulate the mRNA transcription and other functional signaling pathways in cell autophagy, displaying promising roles in human cancer pathogenesis and therapeutic response. This article mainly reviews the cutting-edge research advances about the interactions between ncRNAs and autophagy in OC. This review not only summarizes the underlying mechanisms of dynamic ncRNA-autophagy association in OC, but also discusses their prognostic implications and therapeutic biomarkers. The aim of this review was to provide a more in-depth knowledge framework exploring the ncRNA-autophagy crosstalk and highlight the promising treatment strategies for OC patients.

Keywords: cancer pathogenesis; cell autophagy; non-coding RNAs; ovarian cancer; prognosis.

Publication types

Review

Grants and funding

This study is supported by grants from the China Postdoctoral Science Foundation (2021T140754, 2020M672521).