Cyclic neutropenia in identical twins

Am J Med. 1986 May;80(5):994-6. doi: 10.1016/0002-9343(86)90651-0.


Cyclic neutropenia developed in identical twin girls. The onset of neutropenia in these children occurred three years apart. Neutrophil cycling diminished, and symptoms decreased in the initially affected twin during a five-year follow-up. Some cases of cyclic neutropenia may be genetically determined; however, the onset and clinical manifestations may be modified by other internal and external factors. There may also be a prodromal period during which neutrophils cycle, but the patient is neither neutropenic nor symptomatic.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Agranulocytosis / blood*
  • Diseases in Twins*
  • Female
  • Humans
  • Leukocyte Count
  • Neutropenia / blood*
  • Neutropenia / genetics
  • Neutrophils / pathology
  • Periodicity*
  • Time Factors
  • Twins, Monozygotic