Clinicopathologic correlation of lipidization and detachment of the retinal pigment epithelium

Am J Ophthalmol. 1986 May 15;101(5):576-83. doi: 10.1016/0002-9394(86)90948-7.


A 49-year-old woman had a few small drusen-like lesions and one larger area of depigmentation in the right fundus. The pin-point lesions corresponded to single enlarged retinal pigment epithelial cells with lipid accumulation and the larger area represented a small, localized retinal pigment epithelial detachment (soft druse). Lipoidal degeneration of individual retinal pigment epithelial cells may be a mechanism of nodular drusen formation. The soft druse was associated with thickening of the basement membrane of the retinal pigment epithelium.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Lipidoses / pathology
  • Microscopy
  • Microscopy, Electron
  • Middle Aged
  • Pigment Epithelium of Eye / pathology
  • Retinal Detachment / pathology*