Malignant transformation of a solitary tracheal papilloma in the absence of human papillomavirus infection in a patient with 48, XYYY syndrome: case report

J Cardiothorac Surg. 2023 Apr 17;18(1):144. doi: 10.1186/s13019-023-02275-5.

Abstract

The diagnosis and management of tracheobronchial papilloma is challenging due to its rarity, and non-specific presenting symptoms. Small percentage undergoes malignant transformation. Herein, we report an unusual case of tracheal papilloma initially misdiagnosed as chronic obstructive pulmonary disease (COPD) in 36-year-old male with triple Y syndrome. It was successfully treated with local debridement and brachytherapy. To the best of our knowledge, this is the first description of brachytherapy for such a condition.

Keywords: Carcinoma; Papilloma; Trachea.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cell Transformation, Neoplastic / pathology
  • Human Papillomavirus Viruses
  • Humans
  • Male
  • Papilloma* / diagnosis
  • Papilloma* / pathology
  • Papilloma* / surgery
  • Papillomavirus Infections* / complications
  • Papillomavirus Infections* / diagnosis
  • Papillomavirus Infections* / pathology
  • Tracheal Neoplasms* / diagnosis
  • Tracheal Neoplasms* / pathology