COVID-19 Vaccines Are Safely Tolerated in Adolescents with Cutaneous Mastocytosis

Int Arch Allergy Immunol. 2023;184(8):776-782. doi: 10.1159/000530125. Epub 2023 Apr 18.


Introduction: The management of the COVID-19 vaccine in children with mastocytosis is unclear due to a lack of data. In the current study, we aimed to evaluate the adverse reactions following COVID-19 vaccination in adolescents with cutaneous mastocytosis (CM).

Methods: This study included 27 paediatric patients who were diagnosed with CM and were followed up in the paediatric allergy department of a tertiary care children's hospital.

Results: The median (IQR) age of the patients at the time of COVID-19 vaccination was 180 (156-203) months. Forty-four per cent of patients were vaccinated with the COVID-19 vaccine. Among all participants, the vaccination rate was found to be higher in older children, those who had been diagnosed with MPCM, and those who had not been infected with COVID-19 (p = 0.019, p = 0.009, p = 0.002, respectively). A total of 23 doses of the COVID-19 vaccine, including two doses of Sinovac/CoronaVac and 21 doses of Pfizer/BioNTech, were administered to 12 paediatric patients with CM. One of the patients had a history of intense itch, erythematous urticarial plaques, and had an exacerbation of existing skin lesions within 24-48 h after both doses of Pfizer/BioNTech vaccination.

Conclusion: The COVID-19 vaccination of patients with CM in this series seems to be safe, and the rate of adverse events was comparable to that in the general population. These results found in adolescents with CM are in line with the existing evidence that CM does not preclude vaccination in children.

Keywords: Adverse reactions; Allergic reactions; COVID-19 vaccines; Cutaneous mastocytosis; Paediatric-onset mastocytosis.

MeSH terms

  • Adolescent
  • COVID-19 Vaccines* / adverse effects
  • COVID-19* / prevention & control
  • Child
  • Humans
  • Infant
  • Mastocytosis, Cutaneous*
  • Urticaria*
  • Vaccination / adverse effects
  • Vaccines*


  • COVID-19 Vaccines
  • sinovac COVID-19 vaccine
  • Vaccines