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. 2023 Aug;71(8):2451-2461.
doi: 10.1111/jgs.18371. Epub 2023 Apr 19.

Investigation of the association of weight loss with radiographic hip osteoarthritis in older community-dwelling female adults

Zubeyir Salis  1 , Li-Yung Lui  2 , Nancy E Lane  3 , Kristine Ensrud  4   5 , Amanda Sainsbury  6
Affiliations

Investigation of the association of weight loss with radiographic hip osteoarthritis in older community-dwelling female adults

Zubeyir Salis et al. J Am Geriatr Soc. 2023 Aug.

Abstract

Objective: Most guidelines recommending weight loss for hip osteoarthritis are based on research on knee osteoarthritis. Prior studies found no association between weight loss and hip osteoarthritis, but no previous studies have targeted older adults. Therefore, we aimed to determine whether there is any clear benefit of weight loss for radiographic hip osteoarthritis in older adults because weight loss is associated with health risks in older adults.

Methods: We used data from white female participants aged ≥65 years from the Study of Osteoporotic Fractures. Our exposure of interest was weight change from baseline to follow-up at 8 years. Our outcomes were the development of radiographic hip osteoarthritis (RHOA) and the progression of RHOA over 8 years. Generalized estimating equations (clustering of 2 hips per participant) were used to investigate the association between exposure and outcomes adjusted for major covariates.

Results: There was a total of 11,018 hips from 5509 participants. There was no associated benefit of weight loss for either of our outcomes. The odds ratios (95% confidence intervals) for the development and progression of RHOA were 0.99 (0.92-1.07) and 0.97 (0.86-1.09) for each 5% weight loss, respectively. The results were consistent in sensitivity analyses where participants were limited to those who reported trying to lose weight and who also had a body mass index in the overweight or obese range.

Conclusion: Our findings suggest no associated benefit of weight loss in older female adults in the structure of the hip joint as assessed by radiography.

Keywords: aging; female; hip; osteoarthritis; weight loss.

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Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

Zubeyir Salis and Amanda Sainsbury own 50% of each of the shares in Zuman International, which receives royalties and other payments for educational resources and services in adult weight management and research methodology. Amanda Sainsbury additionally reports receiving presentation fees and travel reimbursements from Eli Lilly and Co, the Pharmacy Guild of Australia, Novo Nor-disk, the Dietitians Association of Australia, Shoalhaven Family Medical Centres, the Pharmaceutical Society of Australia, and Metagenics, and serving on the Nestlé Health Science Optifast VLCD advisory board from 2016 to 2018. Li-Yung Lui, Nancy E. Lane, and Kristine Ensrud report no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Selection of participants. BMI, body mass index; RHOA, radiographic osteoarthritis; SOF, the study of osteoporotic fractures.
FIGURE 2
FIGURE 2
Outcomes of development of RHOA and progression of RHOA. (A). Univariate analysis. (B). Multivariable analysis. The estimates are reported as point estimates of 5% weight loss from baseline to the 8-year follow-up visit. Multivariable analyses were adjusted for the baseline values of age, weight, calcaneus bone mineral density, use of nonsteroidal anti-inflammatory drugs (NSAIDs), smoking status, physical activity status, and the severity of hip osteoarthritis as assessed by radiography (sum of the score from radiography of individual structural features of the hip). RHOA, Radiographic Hip Osteoarthritis.
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