A Phase II Redifferentiation Trial with Dabrafenib-Trametinib and 131I in Metastatic Radioactive Iodine Refractory BRAF p.V600E Mutated Differentiated thyroid Cancer

Clin Cancer Res. 2023 Apr 19;CCR-23-0046. doi: 10.1158/1078-0432.CCR-23-0046. Online ahead of print.


Purpose: To evaluate the efficacy and safety of dabrafenib-trametinib-131I for the treatment of radioactive iodine refractory metastatic differentiated thyroid cancer (DTC) with a BRAFp.V600E mutation.

Experimental design: A prospective phase II trial including patients with RECIST progression within 18 months and no lesion >3 cm. Following a baseline recombinant human (rh)TSH-stimulated diagnostic whole-body scan (dc1-WBS), dabrafenib and trametinib were given for 42 days. A second rhTSH-stimulated dc WBS (dc2-WBS) was done at day 28 and 131I (5.5 GBq-150mCi after rhTSH) was administered at day 35. Primary endpoint was the 6-months RECIST objective response rate. In case of partial response (PR) at 6 or 12 months, a second treatment course could be given. Among 24 enrolled patients, 21 were evaluable at 6 months.

Results: Abnormal 131I uptake was present on 5%, 65% and 95% of the dc1-WBS, dc2-WBS and post-therapy scan, respectively. At 6 months, PR was achieved in 38%, stable disease in 52% and progressive disease (PD) in 10%. Ten patients received a second treatment course: one complete response and 6 PR were observed at 6 months. The median progression free survival (PFS) was not reached. The 12 and 24-months PFS were 82% and 68%, respectively. One death due to PD occurred at 24 months. Adverse events (AEs) occurred in 96% of the patients with 10 grade 3-4 AEs in 7 patients.

Conclusion: Dabrafenib-trametinib is effective in BRAFp.V600E mutated DTC patients for restoring 131I uptake with partial response observed 6 months after 131I administration in 38% of the patients.