Detailed curriculum vitae of HER2-targeted therapy

Pharmacol Ther. 2023 May;245:108417. doi: 10.1016/j.pharmthera.2023.108417. Epub 2023 Apr 17.


With the booming development of precision medicine, molecular targeted therapy has been widely used in clinical oncology treatment due to a smaller number of side effects and its superior accuracy compared to that of traditional strategies. Among them, human epidermal growth factor receptor 2 (HER2)-targeted therapy has attracted considerable attention and has been used in the clinical treatment of breast and gastric cancer. Despite excellent clinical effects, HER2-targeted therapy remains in its infancy due to its resulting inherent and acquired resistance. Here, a comprehensive overview of HER2 in numerous cancers is presented, including its biological role, involved signaling pathways, and the status of HER2-targeted therapy.

Keywords: Cancer; HER2; Inhibitor; Resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Breast Neoplasms* / drug therapy
  • Drug Resistance, Neoplasm*
  • Female
  • Humans
  • Molecular Targeted Therapy / methods
  • Signal Transduction


  • ERBB2 protein, human