D-penicillamine-induced polymyositis in patients with rheumatoid arthritis

Arthritis Rheum. 1986 Apr;29(4):560-4. doi: 10.1002/art.1780290416.


Among 329 patients with rheumatoid arthritis treated with D-penicillamine (DP), we found 4 cases of polymyositis. This incidence was significantly higher than the expected coincidence of rheumatoid arthritis and polymyositis/dermatomyositis or than the presumed frequency of this complication among patients treated with DP. In the present report, we summarize and discuss the clinical findings in DP-induced polymyositis/dermatomyositis in our patients and others described in the literature.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Middle Aged
  • Myositis / chemically induced*
  • Penicillamine / administration & dosage
  • Penicillamine / adverse effects
  • Penicillamine / therapeutic use*
  • Time Factors


  • Penicillamine