Impact of therapeutic strategy on disease-free and overall survival of early-stage cervical cancer: Surgery alone versus preoperative radiation

Cancer Rep (Hoboken). 2023 May;6(5):e1823. doi: 10.1002/cnr2.1823. Epub 2023 Apr 19.

Abstract

Background and objectives: There is no international consensus for management of early-stage cervical cancer (ESCC). This study aimed to retrospectively investigate disease-free survival (DFS) and overall survival (OS) in patients with ESCC according to the therapeutic strategy used, surgery alone versus preoperative radiation following by surgery.

Methods: Data were retrospectively collected from 1998 to 2015 using the Gynecological Cancer Registry of the Côte d'Or. The inclusion criteria were FIGO 2018 ≤ IB2; squamous cell carcinoma, adenocarcinoma or adenosquamous type. Survival curves were compared using the log-rank test.

Results: One hundred twenty-six patients were included. Median survival was 90 months. There was no significant difference in DFS (HR = 0.91, 95%CI [0.32-2.53], p = 0.858) or in OS between surgery alone versus preoperative radiation following by surgery (HR = 0.97, 95%CI [0.31-2.99], p = 0.961). In the subgroup of patients with stage ≥IB1, there was no significant difference in DFS (HR = 3.26, p = 0.2) or in OS (HR = 3.87, p = 0.2).

Conclusion: Our study did not identify any difference in survival according to the treatment strategy. Preoperative radiation following by surgery can be an alternative to surgery alone for ESCC.

Keywords: early cervical cancer; radiotherapy; surgery.

MeSH terms

  • Carcinoma, Squamous Cell* / radiotherapy
  • Carcinoma, Squamous Cell* / surgery
  • Disease-Free Survival
  • Female
  • Humans
  • Neoplasm Staging
  • Retrospective Studies
  • Uterine Cervical Neoplasms* / radiotherapy
  • Uterine Cervical Neoplasms* / surgery