DNA Aneuploidy in Colorectal Adenomas

Br J Cancer. 1986 Apr;53(4):477-81. doi: 10.1038/bjc.1986.75.

Abstract

The frequency of DNA aneuploidy was investigated by flow cytometry in 156 colorectal adenomas including 56 associated with 36 synchronous adenocarcinomas. Nine of 156 adenomas (6%) were DNA aneuploid. DNA aneuploidy correlated with increasing size (P less than 0.005) and histopathological type P less than 0.05) but not with dysplasia. Adenomas in associated with a synchronous adenocarcinoma did not have an increased incidence of DNA aneuploidy. Adenocarcinomas found in association with adenomas tend to have a lower incidence of DNA aneuploidy then the generality of colorectal cancers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics
  • Adenoma / genetics*
  • Aneuploidy*
  • Colonic Neoplasms / genetics*
  • DNA / analysis
  • DNA / genetics*
  • Flow Cytometry
  • Humans
  • Neoplasms, Multiple Primary / genetics
  • Rectal Neoplasms / genetics*

Substances

  • DNA