Hb J-Antakya or alpha 2 beta (2)65(E9)Lys----Met in a Turkish family and Hb complutense or alpha 2 beta (2)127(H5)Gln----Glu in a Spanish family; correction of a previously published identification

Biochim Biophys Acta. 1986 Jun 5;871(2):229-31. doi: 10.1016/0167-4838(86)90178-0.

Abstract

Almost 10 years ago we reported in this journal the characterization of Hb Hacettepe or alpha 2 beta (2)127(H5)Gln----Glu. Unfortunately, we have to conclude that the original characterization of this Turkish variant was in error. The corrected data are presented in this short communication. The variant (alpha 2 beta (2)65(E9)Lys----Met) was (re)named Hb J-Antakya, after the city where the family resides. An abnormal Hb, observed in a Spanish family and named Hb Complutense, had the beta 127 Gln----Glu substitution, erroneously assigned to the Turkish variant.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Chromatography
  • Chromatography, High Pressure Liquid
  • Hemoglobin J / analysis
  • Hemoglobins, Abnormal* / analysis
  • Humans
  • Peptide Fragments / isolation & purification
  • Spain
  • Trypsin
  • Turkey

Substances

  • Hemoglobins, Abnormal
  • Peptide Fragments
  • hemoglobin Complutense
  • Hemoglobin J
  • hemoglobin J Antakya
  • Trypsin