Intestinal and femoral blood flow autoregulation in developing swine

Biol Neonate. 1986;49(4):229-40. doi: 10.1159/000242536.


Pressure-flow relationships (P/F) in the small intestine or hindlimb circulation were used to examine autoregulation in 104 swine, aged 1 day to 2 months and anesthetized with pentobarbital. The P/F were obtained while perfusion pressure was decreased by compression of the abdominal aorta for 2 min at each pressure. Readjustments in vascular resistance stabilized within 2 min. Intestinal flow decreased with each decrease in pressure in swine 2 weeks old or younger, but was well maintained by 1 month of age. Femoral flow decreased with each decrease in pressure at all ages studied. Control experiments indicated that the observed vascular responses were independent of angiotension-II activity and were not reflex in origin.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging*
  • Animals
  • Animals, Newborn / physiology
  • Aorta, Abdominal
  • Blood Pressure
  • Femur / blood supply*
  • Hemodynamics*
  • Ileum / blood supply
  • Intestine, Small / blood supply*
  • Jejunum / blood supply
  • Ligation
  • Regional Blood Flow
  • Renal Circulation
  • Swine
  • Vascular Resistance