Macrophages - Controlling the Bifurcation Between Tumor Existence or Regression

Tatiana Novobrantseva; Denise Manfra; Ani Nguyen; Igor Feldman

doi:10.1002/adbi.202300047

Macrophages - Controlling the Bifurcation Between Tumor Existence or Regression

Adv Biol (Weinh). 2023 Oct;7(10):e2300047. doi: 10.1002/adbi.202300047. Epub 2023 Apr 21.

Authors

Tatiana Novobrantseva¹, Denise Manfra¹, Ani Nguyen¹, Igor Feldman¹

Affiliation

¹ Research and Development, Verseau Therapeutics, Newton, MA, 02466, USA.

PMID: 37083213
DOI: 10.1002/adbi.202300047

Abstract

Macrophages are multifunctional cells that are employed by the tumor to further its growth and adaptation. While tumor-associated macrophages (TAMs) have widely diverse phenotypes, tumors coevolve with the ones that can promote tumorigenesis. Functionally, TAMs/myeloid cells constitute the largest negative influence on the tumor microenvironment and need to be reprogrammed in order to enable successful anti-tumor response in most tumors. It is predicted that successful TAM repolarization has the potential to become a staple of immuno-oncology across most indications.

Keywords: TAM; cancer; immunotherapy; macrophages; tumor microenvironment.