COVID-19 in Patients with Chronic Lung Disease

Clin Chest Med. 2023 Jun;44(2):385-393. doi: 10.1016/j.ccm.2022.11.013. Epub 2022 Nov 22.


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes an acute respiratory tract infection known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 enters cells by binding the ACE2 receptor and coreceptors notably TMPRSS2 or Cathepsin L. Severe COVID-19 infection can lead to acute lung injury. Below we describe the current evidence of the impact of common chronic lung diseases (CLDs) on the development of COVID-19. The impact of treatment of CLD on COVID-19 and any risk of vaccination in patients with CLD are considered.

Keywords: Asthma; COPD; COVID-19 susceptibility; Chronic lung disease; Cystic fibrosis; Interstitial lung disease; Pulmonary arterial hypertension; Vaccination.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19* / metabolism
  • Humans
  • Lung
  • Peptidyl-Dipeptidase A / metabolism
  • SARS-CoV-2 / metabolism


  • Peptidyl-Dipeptidase A