Roles of DNA damage in renal tubular epithelial cells injury

Peipei Wang; Jing Ouyang; Zhanjun Jia; Aihua Zhang; Yunwen Yang

doi:10.3389/fphys.2023.1162546

Roles of DNA damage in renal tubular epithelial cells injury

Front Physiol. 2023 Apr 6:14:1162546. doi: 10.3389/fphys.2023.1162546. eCollection 2023.

Authors

Peipei Wang^{1

2

3}, Jing Ouyang^{1

2

3}, Zhanjun Jia^{1

2

3}, Aihua Zhang^{1

2

3}, Yunwen Yang^{1

2

3}

Affiliations

¹ Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.
² Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.
³ Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China.

Abstract

The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been confirmed as common pathogenesis of acute kidney injury and chronic kidney disease. Reactive oxygen species (ROS) induced DNA damage is one of the most common types of DNA damage involved in the pathogenesis of acute kidney injury and chronic kidney disease. In recent years, several developments have been made in the field of DNA damage. Herein, we review the roles and developments of DNA damage and DNA damage response in renal tubular epithelial cell injury in acute kidney injury and chronic kidney disease. In this review, we conclude that focusing on DNA damage and DNA damage response may provide valuable diagnostic biomarkers and treatment strategies for renal diseases including acute kidney injury and chronic kidney disease.

Keywords: AKI (acute kidney injury); CKD—chronic kidney disease; DDR; DNA damage; DNA repair; tubular epithelial cells.

Publication types

Review

Grants and funding

This study was supported by the National Key Research and Development Program (2022YFC2705100, 2019YFA0802700, 2019YFA0802702) to AZ, the National Natural Science Foundation of China (81530023 to AZ, 82090022 to AZ, 81830020 to AZ, 82070701, 82270773, 81873599 to ZJ, 81700642 to YY, 81974084 to SH, 82170754 to YZ), and Nanjing Health Technology Development Program (ZKX22050 to YY).