Exploring the heterogeneity of white adipose tissue in mouse and man

Curr Opin Genet Dev. 2023 Jun:80:102045. doi: 10.1016/j.gde.2023.102045. Epub 2023 Apr 23.


Adipose tissue is a heterogeneous organ, comprising cell types, including mature adipocytes, progenitor cells, immune cells, and vascular cells. Here, we discuss the heterogeneity of human and mouse white adipose tissue in general and white adipocytes specifically, focusing on how our understanding of adipocyte subpopulations has expanded with the advent of single nuclear RNA sequencing and spatial transcriptomics. Furthermore, we discuss critical remaining questions regarding how these distinct populations arise, how their functions differ from one another, and which potentially contribute to metabolic pathophysiology.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adipocytes, White / metabolism
  • Adipose Tissue*
  • Adipose Tissue, White* / metabolism
  • Humans
  • Stem Cells / physiology