Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986 Apr;5(4):823-6.

The Relation Between the Divergence of Sequence and Structure in Proteins

Free PMC article
Comparative Study

The Relation Between the Divergence of Sequence and Structure in Proteins

C Chothia et al. EMBO J. .
Free PMC article

Abstract

Homologous proteins have regions which retain the same general fold and regions where the folds differ. For pairs of distantly related proteins (residue identity approximately 20%), the regions with the same fold may comprise less than half of each molecule. The regions with the same general fold differ in structure by amounts that increase as the amino acid sequences diverge. The root mean square deviation in the positions of the main chain atoms, delta, is related to the fraction of mutated residues, H, by the expression: delta(A) = 0.40 e1.87H.

Similar articles

See all similar articles

Cited by 593 articles

See all "Cited by" articles

References

    1. J Mol Biol. 1977 May 25;112(3):535-42 - PubMed
    1. J Mol Biol. 1985 Mar 20;182(2):317-29 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2674-8 - PubMed
    1. J Mol Biol. 1979 Jan 25;127(3):309-38 - PubMed
    1. J Mol Biol. 1979 Nov 15;134(4):781-804 - PubMed

Publication types

LinkOut - more resources

Feedback