Verapamil and breast-feeding

Eur J Clin Pharmacol. 1986;30(1):125-6. doi: 10.1007/BF00614209.

Abstract

Concentrations of verapamil and norverapamil were measured in the plasma and breast milk of a woman receiving 120 mg verapamil three times daily. Whilst the concentrations of verapamil in breast milk averaged about 64% of those in maternal plasma no drug could be detected in the plasma of the infant. It is concluded that maternal therapy with verapamil does not pose a hazard to the suckling infant.

MeSH terms

  • Adult
  • Breast Feeding*
  • Digoxin / blood
  • Digoxin / metabolism
  • Female
  • Humans
  • Milk, Human / metabolism*
  • Verapamil / adverse effects
  • Verapamil / analogs & derivatives
  • Verapamil / blood
  • Verapamil / metabolism*

Substances

  • Digoxin
  • norverapamil
  • Verapamil