Abstract
The extracellular GABA concentration in the rat striatum was measured by the microdialysis technique. Addition of pergolide (10(-4) M) to the perfusion medium decreased the GABA overflow induced by high K+ but apomorphine (10(-4) M) had no effect on the GABA overflow. When sulpiride (10(-4) M) was added to the perfusion medium, the pergolide effect on stimulated GABA overflow was abolished. The results indicate that D2-receptors are able to modulate GABA overflow in the striatum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apomorphine / pharmacology*
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Corpus Striatum / drug effects*
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Corpus Striatum / metabolism
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Dialysis
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Ergolines / pharmacology*
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In Vitro Techniques
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Male
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Perfusion
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Pergolide
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Potassium / pharmacology
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects
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Receptors, Dopamine / metabolism
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gamma-Aminobutyric Acid / metabolism*
Substances
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Ergolines
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Receptors, Dopamine
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Pergolide
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gamma-Aminobutyric Acid
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Apomorphine
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Potassium