The effect of apomorphine and pergolide on the potassium-evoked overflow of GABA in rat striatum studied by microdialysis

Eur J Pharmacol. 1986 Apr 16;123(2):295-8. doi: 10.1016/0014-2999(86)90671-0.

Abstract

The extracellular GABA concentration in the rat striatum was measured by the microdialysis technique. Addition of pergolide (10(-4) M) to the perfusion medium decreased the GABA overflow induced by high K+ but apomorphine (10(-4) M) had no effect on the GABA overflow. When sulpiride (10(-4) M) was added to the perfusion medium, the pergolide effect on stimulated GABA overflow was abolished. The results indicate that D2-receptors are able to modulate GABA overflow in the striatum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apomorphine / pharmacology*
  • Corpus Striatum / drug effects*
  • Corpus Striatum / metabolism
  • Dialysis
  • Ergolines / pharmacology*
  • In Vitro Techniques
  • Male
  • Perfusion
  • Pergolide
  • Potassium / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Ergolines
  • Receptors, Dopamine
  • Pergolide
  • gamma-Aminobutyric Acid
  • Apomorphine
  • Potassium