Despite obvious theoretical and treatment implications, the study of how individuals end the "compulsive" use of substances without formal treatment ("spontaneous remission") remains a relatively neglected topic. This paper reviews the literature germane to spontaneous remission from four substances (opiates, alcohol, food/obesity, and tobacco) selected for their widely variant meanings within the mainstream North American culture. Common processes important to spontaneous remission from these four substances are identified and form the basis of an inductively derived model of spontaneous remission behavior. This model, relevant to interactionist theory, is offered for further, empirical testing.