Radiation synovectomy with 165Dy-FHMA: lymph node uptake and radiation dosimetry calculations

Int J Nucl Med Biol. 1986;12(6):457-65. doi: 10.1016/s0047-0740(86)80008-0.

Abstract

The lymph node uptake of 165Dy was measured in 25 patients treated by radiation synovectomy via intra-articular injection of 165Dy-ferric hydroxide macroaggregates (FHMA). An average of 0.12% of the injected dose was found in the inguinal lymph nodes 19h post injection. This results in a lymph node of 16.6 rad (166 mGy), a dose significantly less than that reported following radiation synovectomy with other radiocolloids. Dosimetry calculations for the intra-articular injection of 165Dy-FHMA are provided in the appendix.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arthritis, Rheumatoid / radiotherapy*
  • Dysprosium / therapeutic use*
  • Female
  • Ferric Compounds / therapeutic use*
  • Half-Life
  • Humans
  • Iron / therapeutic use*
  • Knee Joint
  • Liver / radiation effects
  • Lymph Nodes / radiation effects*
  • Models, Anatomic
  • Ovary / radiation effects
  • Radiometry
  • Radiotherapy Dosage
  • Synovial Membrane / radiation effects*
  • Time Factors

Substances

  • Ferric Compounds
  • Dysprosium
  • ferric hydroxide
  • Iron