An Assessment of Current Clinician-Reported and Patient-Reported Outcome Measures for Alopecia Areata: A Scoping Review

Eric Xia; Sara J Li; Lara Drake; Sophia Reyes-Hadsall; Carol Mita; Aaron M Drucker; Arash Mostaghimi

doi:10.1016/j.jid.2023.02.020

An Assessment of Current Clinician-Reported and Patient-Reported Outcome Measures for Alopecia Areata: A Scoping Review

J Invest Dermatol. 2023 Jul;143(7):1133-1137.e12. doi: 10.1016/j.jid.2023.02.020. Epub 2023 Apr 28.

Authors

Eric Xia¹, Sara J Li², Lara Drake², Sophia Reyes-Hadsall³, Carol Mita⁴, Aaron M Drucker⁵, Arash Mostaghimi⁶

Affiliations

¹ Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Chobanian & Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA.
² Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Tufts University School of Medicine, Boston, Massachusetts, USA.
³ Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miller School of Medicine, University of Miami, Miami, Florida, USA.
⁴ Countway Library, Harvard Medical School, Boston, Massachusetts, USA.
⁵ Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada; Department of Medicine, Women's College Hospital, Toronto, Ontario, Canada.
⁶ Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: amostaghimi@bwh.harvard.edu.

PMID: 37115113
DOI: 10.1016/j.jid.2023.02.020

Abstract

Although progress has been made in developing outcome measures for AA, the use of these measures remains unstandardized. A scoping review was conducted to identify the clinician-reported outcome measures (ClinROMs) and patient-reported outcome measures (PROMs) used in assessing and treating AA, the results of which revealed heterogeneity in AA outcome measures. Of 23 research studies ultimately included, only 2 ClinROMs were used by >15% of studies; likewise, of 110 clinical trials evaluated, numerous outcome instruments were used, but only one ClinROM was used by >5% of trials (Severity of Alopecia Tool). These results suggest the need for consensus and standardization in both research and trial settings.

Keywords: AA; COS; ClinROM; HRQoL; PROM; SALT; Severity of Alopecia Tool; alopecia areata; clinician-reported outcome measure; core outcomes set; health-related quality of life; patient-reported outcome measure.

Publication types

Scoping Review

MeSH terms

Alopecia / diagnosis
Alopecia / therapy
Alopecia Areata* / drug therapy
Alopecia Areata* / therapy
Humans
Outcome Assessment, Health Care
Patient Reported Outcome Measures
Psychometrics

Supplementary concepts

Diffuse alopecia