Spontaneous bacterial peritonitis caused by Listeria monocytogenes: A rare infection with very high leukocyte counts in ascitic fluid-case report and review of the literature

Clin Res Hepatol Gastroenterol. 2023 May;47(6):102130. doi: 10.1016/j.clinre.2023.102130. Epub 2023 Apr 26.

Abstract

We present a rare case of Listeria monocytogenes-induced spontaneous bacterial peritonitis (SBP) in cirrhosis. Examination of the patient's peritoneal fluid revealed an extremely high leukocyte count. We suspect, that the patient belongs to 1% of individuals in which Listeria monocytogenes is part of the intestinal flora. Cephalosporins as empiric antibiotics have a Listeria gap. A combination of aminopenicillin and aminoglycoside is recommended. Therefore, early microbiological diagnosis from ascites and blood is essential. Listeria should be considered as a rare cause of SBP, especially in case of very high leukocyte count in peritoneal fluid or lack of response to empiric therapy.

Keywords: Infection; Spontaneous bacterial peritonitis, Cirrhosis, Listeria monocytogenes, Ascites.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Ascites / complications
  • Ascitic Fluid
  • Bacterial Infections* / drug therapy
  • Humans
  • Leukocyte Count
  • Listeria monocytogenes*
  • Listeriosis* / complications
  • Listeriosis* / diagnosis
  • Listeriosis* / drug therapy
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / drug therapy
  • Peritonitis* / diagnosis
  • Peritonitis* / drug therapy

Substances

  • Anti-Bacterial Agents