Prenatal developmental disturbances in the limbic allocortex in schizophrenics

J Neural Transm. 1986;65(3-4):303-26. doi: 10.1007/BF01249090.


Sixty-four autopsied brains of schizophrenic patients were neuropathologically examined and compared with 10 brains of non-schizophrenic controls. Clinical diagnoses were established retrospectively according to the Research Diagnostic Criteria and the International Classification of Diseases. We found: brains without deviations of the sulcogyral pattern of the temporal lobe or abnormal gross configuration (n = 22); brains with abnormal sulcogyral pattern of the temporal lobe or abnormal gross configuration (n = 42): with definite cytoarchitectonic abnormalities of the rostral entorhinal region in the parahippocampal gyrus and, in 16 cases only, in the ventral insular cortex (n = 20); with equivocal changes of the cytoarchitecture in these two regions (n = 22). Generally, these anatomical abnormalities were asymmetric. The histological findings in the two limbic regions consisted mainly of poorly developed structure in the upper layers, with a heterotopic displacement of single groups of nerve cells in the entorhinal region. Particularly, the disturbed structure of the second layer Pre-alpha in medial and central fields of the entorhinal region, situated in the parahippocampal gyrus (group 2a), suggests a disturbance of neuronal migration in a later phase of cortical development.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Female
  • Gestational Age
  • Humans
  • Limbic System / abnormalities*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Schizophrenia / pathology*
  • Temporal Lobe / abnormalities*