Ferroptosis in cancer stem cells

Pathol Res Pract. 2023 May;245:154492. doi: 10.1016/j.prp.2023.154492. Epub 2023 Apr 26.


Ferroptosis is an iron-dependent form of RCD correlates with the accumulation of markers of lipid peroxidation. Bulks of studies focusing on revealing ferroptosis and its regulators involved in oncogenic pathways. Connection between iron metabolism and abnormal iron metabolism in CSCs synergistically making ferroptosis a target process of great potential in combating with CSCs to improve therapeutic effectiveness and reverse resistance. Ferroptosis inducers could specifically induce CSCs death in tumors, predisposing ferroptosis to a target in killing CSCs to overcome cancer resistances. By ferroptosis induction and other cell death pathways in CSCs, cancer therapeutic outcome would be improved.

Keywords: Cancer stem cells; Ferroptosis; Targeted therapy.

Publication types

  • Review

MeSH terms

  • Cell Death
  • Ferroptosis*
  • Humans
  • Iron
  • Lipid Peroxidation
  • Neoplasms*
  • Neoplastic Stem Cells


  • Iron