Removal of antibiotic resistant bacteria in wastewater by aggregation-induced emission photosensitizer

Abstract

The spread of antibiotic resistant bacteria from wastewater to the environment will pose serious threats to human health. It is a potential solution to prepare photosensitizers with broad-spectrum antibacterial activity for use in the photo-oxidation process to supplement the wastewater treatment system. Here, an aggregation-induced emission photosensitizer with D-π-A structure (TBTPy) has been reasonably designed and successfully developed. TBTPy can generate singlet oxygen with extraordinarily high efficiency under white-light irradiation owing to the small singlet-triplet energy gap. TBTPy has a rapid and efficient photo-oxidative killing effect on bacteria and fungi (such as MRSA, S. aureus, E. coli and C. albicans). TBTPy kills bacteria by binding to bacterial surface and releasing singlet oxygen to destroy cell membrane, leading to leakage of bacterial genetic material. This successful case can provide practical guidance for the subsequent development of AIE photosensitizers.

Keywords: Aggregation-induced emission photosensitizer; Antibiotic resistant bacteria; Photo-oxidation; Singlet oxygen.