Orbital MALT lymphoma with amyloid deposition

Orbit. 2024 Aug;43(4):526-530. doi: 10.1080/01676830.2023.2203750. Epub 2023 May 1.

Abstract

MALT lymphoma is a commonly encountered orbital tumor, and primary amyloidosis is frequently found to be an independent orbital lesion. Orbital MALT lymphoma with associated amyloid deposition is considered rare, with only 12 cases previously published. We describe a 33-year-old man, the youngest patient reported to-date, with a mass in the superonasal quadrant of the right anterior orbit. Pathology demonstrated extranodal marginal zone lymphoma in mucosa-associated lymphoid tissue with associated amyloid deposition. Systemic work-up revealed no other site of either lymphoma or amyloidosis. The patient underwent local irradiation and subsequent surgical resection of the residual mass. Persistent lymphoma was found and treated with rituximab.

Keywords: Amyloidosis; Lymphoma; Orbit.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amyloid / metabolism
  • Amyloidosis / metabolism
  • Amyloidosis / pathology
  • Antineoplastic Agents, Immunological / therapeutic use
  • Humans
  • Lymphoma, B-Cell, Marginal Zone* / pathology
  • Magnetic Resonance Imaging
  • Male
  • Orbital Neoplasms* / diagnostic imaging
  • Orbital Neoplasms* / metabolism
  • Orbital Neoplasms* / pathology
  • Rituximab / therapeutic use
  • Tomography, X-Ray Computed

Substances

  • Rituximab
  • Amyloid
  • Antineoplastic Agents, Immunological