[Receptor substances of brain mitochondria sensitive to neuromediators]

Abstract

The action of some neurotransmitters and their derivatives on succinate dehydrogenase and cytochrome oxidase of rat brain mitochondria was studied in vitro. Alpha--adrenoreceptor blocking agents phentolamine and dibenzyline abolished the inhibitory action of the native forms of catecholamines (norepinephrine, epinephrine, isoproterenol) on the enzymatic activity under study. Relationships among catecholamines, cyclic 3',5'--AMP, and cortisone in their influence on these enzymes were studied. The data obtained indicate the existence of alpha--type adrenoreceptors in the brain mitochondria which can be responsible for the regulatory influences of catecholamines on functional activity of mitochondria.