Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Scott M Plafker; Tyler Titcomb; Katarzyna Zyla-Jackson; Aneta Kolakowska; Terry Wahls

doi:10.1097/IN9.0000000000000022

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Immunometabolism (Cobham). 2023 Apr 27;5(2):e00022. doi: 10.1097/IN9.0000000000000022. eCollection 2023 Apr.

Authors

Scott M Plafker^{1

2}, Tyler Titcomb³, Katarzyna Zyla-Jackson^{1

2}, Aneta Kolakowska¹, Terry Wahls³

Affiliations

¹ Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
² Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
³ Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Abstract

This review summarizes the cellular and molecular underpinnings of autoimmune demyelinating optic neuritis (ADON), a common sequela of multiple sclerosis and other demyelinating diseases. We further present nutritional interventions tested for people with multiple sclerosis focusing on strategies that have shown efficacy or associations with disease course and clinical outcomes. We then close by discuss the potential dietary guidance for preventing and/or ameliorating ADON.

Keywords: diet; experimental autoimmune encephalomyelitis; multiple sclerosis; nutrition; optic nerve; optic neuritis.

Publication types

Review