Dental needs and conditions of individuals with Lowe syndrome: An observational study

Spec Care Dentist. 2024 Mar-Apr;44(2):502-512. doi: 10.1111/scd.12870. Epub 2023 May 2.


Introduction: Lowe syndrome (LS) is an uncommon condition that affects the brain, kidneys, nervous system, and eyes, predominantly in males. The aim of this study was to examine dental conditions, dental treatments, and access and/or barriers to care for those with LS compared to healthy individuals.

Methods: Surveys assessing dental conditions, dental treatments, and access and/or barriers to care were administered to families in the Lowe Syndrome Association and families with healthy children who had dental appointments at the Tufts University School of Dental Medicine (TUSDM) pediatric dental clinic. One parent or a guardian of pediatric patients with LS or not at TUSDM was asked to complete an online survey.

Results: One hundred and eight surveys were obtained (n:58 from the LS group and n:50 from the healthy group). The LS group was significantly more likely (p < .05) to report "crooked/misaligned teeth," "difficult time chewing," "bad breath," and "mouth cysts" and was significantly less likely to report 6-month examination, "cleaning," and "filling." The LS group reported significantly greater difficulty locating a dentist.

Conclusion: The findings of this study indicate that individuals with LS are more vulnerable to developing severe dental conditions and experiencing difficulties in accessing dental care than healthy individuals. Additionally, those who present with this syndrome may be less likely to receive specific necessary dental treatments. As a result, it is essential to offer appropriate dental care and support to individuals with LS to guarantee they achieve optimal oral health.

Keywords: dental care; dental clinics; health services accessibility; oculocerebrorenal syndrome.

Publication types

  • Observational Study

MeSH terms

  • Child
  • Health Services Accessibility
  • Health Status
  • Humans
  • Male
  • Oculocerebrorenal Syndrome*
  • Oral Health
  • Surveys and Questionnaires