Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug;270(8):3958-3969.
doi: 10.1007/s00415-023-11728-9. Epub 2023 May 3.

Decreased aperiodic neural activity in Parkinson's disease and dementia with Lewy bodies

Yevgenia Rosenblum  1   2   3 , Tamara Shiner  2   3   4 , Noa Bregman  2   3   4 , Nir Giladi  1   2   5   3   4 , Inbal Maidan  1   3   4 , Firas Fahoum  5   3 , Anat Mirelman  6   7   8
Affiliations

Decreased aperiodic neural activity in Parkinson's disease and dementia with Lewy bodies

Yevgenia Rosenblum et al. J Neurol. 2023 Aug.

Abstract

Neural oscillations and signal complexity have been widely studied in neurodegenerative diseases, whereas aperiodic activity has not been explored yet in those disorders. Here, we assessed whether the study of aperiodic activity brings new insights relating to disease as compared to the conventional spectral and complexity analyses. Eyes-closed resting-state electroencephalography (EEG) was recorded in 21 patients with dementia with Lewy bodies (DLB), 28 patients with Parkinson's disease (PD), 27 patients with mild cognitive impairment (MCI) and 22 age-matched healthy controls. Spectral power was differentiated into its oscillatory and aperiodic components using the Irregularly Resampled Auto-Spectral Analysis. Signal complexity was explored using the Lempel-Ziv algorithm (LZC). We found that DLB patients showed steeper slopes of the aperiodic power component with large effect sizes compared to the controls and MCI and with a moderate effect size compared to PD. PD patients showed steeper slopes with a moderate effect size compared to controls and MCI. Oscillatory power and LZC differentiated only between DLB and other study groups and were not sensitive enough to detect differences between PD, MCI, and controls. In conclusion, both DLB and PD are characterized by alterations in aperiodic dynamics, which are more sensitive in detecting disease-related neural changes than the traditional spectral and complexity analyses. Our findings suggest that steeper aperiodic slopes may serve as a marker of network dysfunction in DLB and PD features.

Keywords: 1/f power-law; Aperiodic activity; Dementia with Lewy bodies; Lempel–Ziv complexity; Neural oscillations; Parkinson’s disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abásolo D, Hornero R, Gómez C, García M, López M (2006) Analysis of EEG background activity in Alzheimer’s disease patients with Lempel-Ziv complexity and central tendency measure. Med Eng Phys 28(4):315–322. https://doi.org/10.1016/j.medengphy.2005.07.004 - DOI - PubMed
    1. Abásolo D, Simons S, Morgado da Silva R, Tononi G, Vyazovskiy VV (2015) Lempel-Ziv complexity of cortical activity during sleep and waking in rats. J Neurophysiol 113(7):2742–2752. https://doi.org/10.1152/jn.00575.2014 - DOI - PubMed - PMC
    1. Adelhöfer N, Paulus T, Mückschel M, Bäumer T, Bluschke A, Takacs A, Tóth-Fáber E, Tárnok Z, Roessner V, Weissbach A, Münchau A (2021) Increased scale-free and aperiodic neural activity during sensorimotor integration—a novel facet in Tourette syndrome. Brain Commun 3(4):fcab250. https://doi.org/10.1093/braincomms/fcab250 - DOI - PubMed - PMC
    1. Babiloni C, Barry RJ, Başar E, Blinowska KJ, Cichocki A, Drinkenburg WH, Klimesch W, Knight RT, da Silva FL, Nunez P, Oostenveld R (2020) International Federation of Clinical Neurophysiology (IFCN)–EEG research workgroup: recommendations on frequency and topographic analysis of resting state EEG rhythms. Part 1: applications in clinical research studies. Clin Neurophysiol 131(1):285–307. https://doi.org/10.1016/j.clinph.2019.06.234 - DOI - PubMed
    1. Bédard C, Destexhe A (2009) Macroscopic models of local field potentials and the apparent 1/f noise in brain activity. Biophys J 96(7):2589–2603. https://doi.org/10.1016/j.bpj.2008.12.3951 - DOI - PubMed - PMC