Assessment of the Efficacy of Cryolipolysis on Abdominal Fat Deposits: A Prospective Study

Aesthetic Plast Surg. 2023 Dec;47(6):2679-2686. doi: 10.1007/s00266-023-03369-0. Epub 2023 May 3.


Background: Cryolipolysis is a non-invasive and efficacious procedure for body contouring. The effectiveness of cryolipolysis has been demonstrated on multiple areas of the body, but on a limited number of subjects. The aim of this study is to demonstrate the effectiveness and the safety of cryolipolysis in the lower abdomen adipose tissue thickness reduction.

Methods: A prospective study on 60 healthy women was carried out using CryoSlim Hybrid device. Each patient underwent two cryolipolysis sessions centered on the abdominal area. The primary endpoint was to decrease the thickness of the abdominal fat deposits. The change in the abdominal circumference and the thickness of the subcutaneous fat layer were assessed. Patient satisfaction and tolerance of the procedure were also taken into account.

Results: A significant reduction of the abdominal circumference and subcutaneous fat layer thickness was observed. The mean decrease in abdominal circumference was 2.10 cm (3.1%) 3 months after the procedure and 4.03 cm (5.8%) 6 months after the procedure. The mean decrease in fat layer thickness was 1.25 cm (43.81%) 3 months after the procedure and 1.61 cm (41.73%) 6 months after the procedure. No major adverse events were noted. All patients were very satisfied, and minimal pain was reported.

Conclusions: Cryolipolysis is an effective technique to treat abdominal localized fat deposits. No major adverse events have been described for this procedure. Our promising results should encourage further studies aimed at optimizing the efficacy of the procedure without a considerable increase in the risks.

Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors .

Keywords: Abdominal fat; Adipocyte apoptosis; Cold therapy; Cryolipolysis; Fat deposits; Non-invasive fat reduction; Nonsurgical body contouring; Subcutaneous fat.

MeSH terms

  • Abdominal Fat / surgery
  • Cryotherapy* / adverse effects
  • Cryotherapy* / methods
  • Female
  • Humans
  • Lipectomy* / methods
  • Patient Satisfaction
  • Prospective Studies
  • Subcutaneous Fat / surgery
  • Treatment Outcome