Voltage-sensitive dyes reveal a modular organization in monkey striate cortex

Nature. 1986 Jun 5-11;321(6070):579-85. doi: 10.1038/321579a0.

Abstract

Voltage-sensitive dyes allow neuronal activity to be studied by non-invasive optical techniques. They provide an attractive means of investigating striate cortex, where important response properties are organized in two dimensions. In the present study, patterns of ocular dominance and orientation selectivity were obtained repeatedly from the same patch of cortex using the dye merocyanine oxazolone, together with current image-processing techniques. The patterns observed agree with most established features of monkey striate cortex and suggest a new unit of cortical organization; one that is modular in structure and which appears to link the organization of orientation selectivity with that of ocular dominance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Coloring Agents
  • Electrophysiology
  • Functional Laterality
  • Macaca fascicularis
  • Macaca nemestrina
  • Orientation
  • Oxazolone / analogs & derivatives
  • Visual Cortex / cytology
  • Visual Cortex / physiology*
  • Visual Perception*

Substances

  • Coloring Agents
  • Oxazolone
  • NK 2367