DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling

Affiliations

• ¹ Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ² Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ³ Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
• ⁴ Monoclonal Antibodies Core Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ⁵ Confocal Microscopy Core Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ⁶ Anatomical Pathology Service, Hospital of León, León, Castilla y León, Spain.
• ⁷ Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ⁸ CNIO-Lilly Cell Signalling and Immunometabolism Section, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ⁹ Spectroscopy and Nuclear Magnetic Resonance Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ¹⁰ Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
• ¹¹ Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
• ¹² Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
• ¹³ Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), L'Hospitalet, Barcelona, Spain.
• ¹⁴ Histopathology Core Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ¹⁵ Cell Signaling and Clinical Proteomics Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
• ¹⁶ Ikerbasque, Basque Foundation for Science, Bilbao, Spain.