Ganglioneuroma Arising in Congenital Melanocytic Nevus in a Patient with Cardiac Anomalies: A Case Report

Int J Surg Pathol. 2024 Feb;32(1):196-200. doi: 10.1177/10668969231171130. Epub 2023 May 4.


A congenital melanocytic nevus is a benign melanocyte proliferation, that may be complicated by malignant transformation. We are reporting a three-year-old girl, who had a giant congenital melanocytic nevus on her back, that was treated by serial surgical excisions with tissue expander insertion. Histopathological examination confirmed the diagnosis of congenital melanocytic nevus with ganglioneuroma. Out of approximately 250 case reports on congenital melanocytic nevus, we identified only two reports of medium/large congenital melanocytic nevus with cutaneous ganglioneuroma. Due to the potential malignant transformation of congenital melanocytic nevus, reporting the features and characteristics of such rare findings may help in further understanding congenital melanocytic nevus, its associations, and prognosis.

Keywords: Saudi Arabia; cardiac anomalies; congenital melanocytic nevus; ganglioneuroma; giant.

Publication types

  • Case Reports

MeSH terms

  • Cell Transformation, Neoplastic
  • Child, Preschool
  • Female
  • Ganglioneuroma* / complications
  • Ganglioneuroma* / diagnosis
  • Ganglioneuroma* / surgery
  • Humans
  • Melanoma* / diagnosis
  • Nevus, Pigmented* / complications
  • Nevus, Pigmented* / diagnosis
  • Nevus, Pigmented* / surgery
  • Skin Neoplasms* / diagnosis
  • Skin Neoplasms* / pathology
  • Skin Neoplasms* / surgery