An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review

Hong Sun; Rong Sun; Yulin Hua; Qianyi Lu; Xinyu Shao

doi:10.3389/fmed.2023.1153805

An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review

Front Med (Lausanne). 2023 Apr 18:10:1153805. doi: 10.3389/fmed.2023.1153805. eCollection 2023.

Authors

Hong Sun¹, Rong Sun¹, Yulin Hua², Qianyi Lu^{3

4}, Xinyu Shao¹

Affiliations

¹ Department of Endocrinology and Metabolism, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, Jiangsu, China.
² The First Clinical Medical College, Soochow University, Suzhou, Jiangsu, China.
³ Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
⁴ Department of Ophthalmology, Changshu No. 1 People's Hospital, Suzhou, Jiangsu, China.

Abstract

Thioredoxin-interacting protein (TXNIP) was first isolated from Vitamin D3-exposed HL60 cells. TXNIP is the main redox-regulating factor in various organs and tissues. We begin with an overview of the TXNIP gene and protein information, followed by a summary of studies that have shown its expression in human kidneys. Then, we highlight our current understanding of the effect of TXNIP on diabetic kidney disease (DKD) to improve our understanding of the biological roles and signal transduction of TXNIP in DKD. Based on the recent review, the modulation of TXNIP may be considered as a new target in the management of DKD.

Keywords: autophagy; diabetic kidney disease; lipid; reactive oxygen species; thioredoxin-interacting protein.

Publication types

Review