An updated minireview of chiral stationary phases (CSPs) based on amino alcohols is presented. In this minireview, we focused on amino alcohols as starting materials in preparation of chiral catalysts for asymmetric organic synthesis and CSPs for chiral separations. Among the various CSPs, we summarized the important developments and applications of the amino alcohol-based Pirkle-type CSPs, ligand exchange CSPs, α-amino acid-derived amino alcohol CSPs, and symmetric CSPs from their first appearance to the present day to propose ideas for the development of new CSPs with improved performance.
Keywords: HPLC; amino alcohol; chiral separation; chiral stationary phases; symmetric CSPs.
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