A new method for predicting signal sequence cleavage sites

Nucleic Acids Res. 1986 Jun 11;14(11):4683-90. doi: 10.1093/nar/14.11.4683.


A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described. The predictive accuracy is estimated to be around 75-80% for both prokaryotic and eukaryotic proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Eukaryotic Cells
  • Prokaryotic Cells
  • Protein Sorting Signals / metabolism*
  • Proteins / metabolism*
  • Structure-Activity Relationship


  • Protein Sorting Signals
  • Proteins