A rare clinical presentation after COVID-19: Manic episode with psychotic features

Psychiatry Res Case Rep. 2023 Jun;2(1):100115. doi: 10.1016/j.psycr.2023.100115. Epub 2023 Apr 19.


Neuropsychiatric manifestations of the COVID-19, caused by SARS-CoV-2, are under close scrutiny as the virus is shown likely to either directly or indirectly affects the central nervous system although it mainly targets the respiratory tract. Here, we describe a middle-aged male who developed acute psychiatric symptoms after a recent COVID-19 infection with no prior personal or family history of psychiatric disorder. Although there are reported cases of diagnosed psychosis or affective disorders following COVID-19 infection in the literature, to our knowledge, this is the first case where the development of autoimmune encephalitis after COVID-19 was considered and ruled out. This case report describes the comprehensive evaluation of all possible organic etiology. We also aimed to discuss possible biological underpinnings of such an exceptional comorbidity.

Keywords: Bipolar disorder; Coronavirus; Neuroimmunology; Neuropsychiatric symptoms; Psychosis; SARS-CoV-2.

Publication types

  • Case Reports