Nickel-Catalyzed Alkylation of Oxindoles with Secondary Alcohols

J Org Chem. 2023 Jun 2;88(11):7162-7171. doi: 10.1021/acs.joc.3c00402. Epub 2023 May 10.

Abstract

Herein, we have demonstrated a simple nickel-catalyzed C-3-selective alkylation of 2-oxindoles using a wide variety of secondary alkyl alcohols. As a special highlight, functionalization of the cholesterol derivative was reported. Control experiments, initial mechanistic studies, and deuterium-labeling experiments were performed for the alkylation process.