Persistent disturbances of cognitive functions in patients with pseudotumor cerebri

Acta Neurol Scand. 1986 Mar;73(3):264-8. doi: 10.1111/j.1600-0404.1986.tb03273.x.

Abstract

In a series of 20 consecutive patients with pseudotumor cerebri, five patients had a protracted course of the disease with complaints of persistent disturbances in learning and memory functions. Neuropsychological examination disclosed a light general intellectual impairment with most marked disturbances in verbal tests. After intensive medical treatment or ventriculo-atrial shunt operation, psychological re-examination showed improvement in the test results in accordance with the improvement of the patients' occupational and social situation. Cognitive dysfunction can be the result of a prolonged course of benign intracranial hypertension, and the term "benign" may be misleading in these cases. However, the intellectual impairment, even when long-standing, seems to be reversible in most patients after medical or surgical measures to lower the intracranial pressure.

MeSH terms

  • Acetazolamide / therapeutic use
  • Adolescent
  • Adult
  • Cognition Disorders / etiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Learning
  • Male
  • Memory
  • Middle Aged
  • Pseudotumor Cerebri / drug therapy
  • Pseudotumor Cerebri / psychology*
  • Psychological Tests

Substances

  • Acetazolamide