Growing up: A NOD2 our microbes

Yadeliz A Serrano Matos; Carrie A Cowardin

doi:10.1016/j.chom.2023.04.014

Growing up: A NOD2 our microbes

Cell Host Microbe. 2023 May 10;31(5):685-687. doi: 10.1016/j.chom.2023.04.014.

Authors

Yadeliz A Serrano Matos¹, Carrie A Cowardin²

Affiliations

¹ Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
² Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: ccowardin@virginia.edu.

PMID: 37167948
DOI: 10.1016/j.chom.2023.04.014

Abstract

In a recent report in Science, Schwarzer and colleagues demonstrate the growth benefits of treatment with Lactiplantibacillus plantarum strain WJL in a preclinical mouse model of chronic undernutrition. L. plantarum influences the somatotropic axis to promote growth through intestinal epithelial NOD2 sensing.

MeSH terms

Animals
Gastrointestinal Microbiome / genetics
Growth / genetics
Growth / physiology
Intestinal Mucosa* / metabolism
Intestinal Mucosa* / microbiology
Malnutrition* / genetics
Malnutrition* / microbiology
Malnutrition* / physiopathology
Malnutrition* / therapy
Mice

Substances

Nod2 protein, mouse

Abstract

MeSH terms

Substances

Grants and funding