Pharmacological effects of baicalin in lung diseases

Front Pharmacol. 2023 Apr 24;14:1188202. doi: 10.3389/fphar.2023.1188202. eCollection 2023.


The flavonoids baicalin and baicalein were discovered in the root of Scutellaria baicalensis Georgi and are primarily used in traditional Chinese medicine, herbal supplements and healthcare. Recently, accumulated investigations have demonstrated the therapeutic benefits of baicalin in treating various lung diseases due to its antioxidant, anti-inflammatory, immunomodulatory, antiapoptotic, anticancer, and antiviral effects. In this review, the PubMed database and ClinicalTrials website were searched with the search string "baicalin" and "lung" for articles published between September 1970 and March 2023. We summarized the therapeutic role that baicalin plays in a variety of lung diseases, such as chronic obstructive pulmonary disease, asthma, pulmonary fibrosis, pulmonary hypertension, pulmonary infections, acute lung injury/acute respiratory distress syndrome, and lung cancer. We also discussed the underlying mechanisms of baicalin targeting in these lung diseases.

Keywords: baicalin; lung cancer; lung disease; lung infection; lung injury.

Publication types

  • Review

Grants and funding

The research leading to these results has received funding from Sichuan University Full-time Postdoctoral Research and Development Fund, Grant/Award Number: 2020SCU12023; PostDoctor Research Project, West China Hospital, Sichuan University, Grant/Award Number: 2018HXBH041. Financial support was received by YL.