Sex Cord-Stromal Tumors of the Ovary

Madeleine Sertic; Kyle M Devins; Esther Oliva; Susanna I Lee; Aoife Kilcoyne

doi:10.1016/j.rcl.2023.02.005

Sex Cord-Stromal Tumors of the Ovary

Radiol Clin North Am. 2023 Jul;61(4):595-608. doi: 10.1016/j.rcl.2023.02.005. Epub 2023 Mar 31.

Authors

Madeleine Sertic¹, Kyle M Devins², Esther Oliva², Susanna I Lee³, Aoife Kilcoyne³

Affiliations

¹ Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: msertic@mgh.harvard.edu.
² Harvard Medical School, Boston, MA, USA; Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.
³ Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

PMID: 37169426
DOI: 10.1016/j.rcl.2023.02.005

Abstract

Ovarian sex cord-stromal tumors (OSCSTs) are a rare group of ovarian neoplasms that can be benign or malignant. They are classified into pure sex cord tumors, pure stromal tumors, and mixed SCST. The most common malignant OSCSTs are adult granulosa cell tumors. In contrast to the more common ovarian epithelial malignancies, OSCSTs present in younger patients, often at early stages, with better prognoses. Imaging features are variable, and pathology is required for diagnosis. However, certain tumors demonstrate characteristic imaging appearances that can be useful in narrowing the differential diagnosis.

Keywords: Adult granulosa cell tumors; Female pelvic imaging; Gynecologic oncology; Juvenile granulosa cell tumors; MR imaging; Sex cord-stromal tumors; Ultrasound.

Publication types

Review

MeSH terms

Adult
Female
Granulosa Cell Tumor* / diagnostic imaging
Granulosa Cell Tumor* / pathology
Humans
Ovarian Neoplasms* / diagnostic imaging
Ovarian Neoplasms* / pathology
Pelvis
Sex Cord-Gonadal Stromal Tumors* / diagnostic imaging
Sex Cord-Gonadal Stromal Tumors* / pathology