Update on Ovarian Sex Cord-Stromal Tumors

Clin Lab Med. 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001.


This article focuses on the recent advances in ovarian sex cord-stromal tumors, predominantly in the setting of their molecular underpinnings. The integration of genetic information with morphologic and immunohistochemical findings in this rare subset of tumors is of clinical significance from refining the diagnostic and prognostic stratifications to genetic counseling.

Keywords: Adult granulosa cell tumor; DICER1; FOXL2; Gynandroblastoma; Juvenile Granulosa cell tumor; Microcystic stromal tumor; Ovary; Sertoli–Leydig cell tumor; Sex cord-stromal tumor.

Publication types

  • Review

MeSH terms

  • DEAD-box RNA Helicases / genetics
  • Female
  • Humans
  • Ovarian Neoplasms* / diagnosis
  • Ovarian Neoplasms* / genetics
  • Ovarian Neoplasms* / pathology
  • Prognosis
  • Ribonuclease III / genetics
  • Sex Cord-Gonadal Stromal Tumors* / diagnosis
  • Sex Cord-Gonadal Stromal Tumors* / genetics
  • Sex Cord-Gonadal Stromal Tumors* / pathology


  • DEAD-box RNA Helicases
  • Ribonuclease III